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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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RNA-seq03:21

RNA-seq

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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AnnoLnc: a web server for systematically annotating novel human lncRNAs.

Mei Hou1, Xing Tang1,2, Feng Tian1,3

  • 1State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Center for Bioinformatics, Peking University, Beijing, 100871, P.R. China.

BMC Genomics
|November 18, 2016
PubMed
Summary
This summary is machine-generated.

AnnoLnc provides systematic annotation for novel human long noncoding RNAs (lncRNAs), aiding in understanding their biological roles. This comprehensive tool offers insights into lncRNA function and regulation.

Keywords:
AnnotationLncRNAsLong noncoding RNAsTranscriptomeWeb server

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Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Long noncoding RNAs (lncRNAs) are crucial in biological processes, but their functions and regulation are not fully understood.
  • The rapid expansion of human lncRNA identification necessitates advanced annotation tools.

Purpose of the Study:

  • To present AnnoLnc, a comprehensive web portal for systematic annotation of novel human lncRNAs.
  • To provide an integrated platform for exploring lncRNA characteristics and functions.

Main Methods:

  • Development of AnnoLnc, a web server integrating over 700 data sources and tool chains.
  • Systematic annotation of lncRNAs covering genomic location, structure, expression, regulation, interactions, and evolution.
  • Implementation of an intuitive web interface and JSON-based Web Service APIs for accessibility.

Main Results:

  • AnnoLnc offers on-the-fly, systematic annotation for newly identified human lncRNAs.
  • The platform provides a broad spectrum of annotation with intuitive visualization.
  • AnnoLnc facilitates the rediscovery of known lncRNA functions and generation of new hypotheses.

Conclusions:

  • AnnoLnc is a unique resource for comprehensive human lncRNA annotation.
  • The tool enhances the understanding of lncRNA biology and function.
  • AnnoLnc supports both interactive analysis and programmatic integration for researchers.