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Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH
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Shear wave elastography imaging for assessing the chronic pathologic changes in advanced diabetic kidney disease
Kamal Hassan1, Norman Loberant2, Nur Abbas3
1Faculty of Medicine in the Galilee, Bar-Ilan University, Safed; Department of Nephrology and Hypertension, Peritoneal Dialysis Unit - Galilee Medical Center.
Therapeutics and Clinical Risk Management
|November 18, 2016
Summary
Shear wave elastography (SWE) offers a non-invasive method to assess kidney stiffness in diabetic kidney disease (DKD). Increased renal parenchymal stiffness correlates with disease severity and can help differentiate chronic kidney disease (CKD) grades.
Area of Science:
- Nephrology
- Medical Imaging
- Biophysics
Background:
- Diabetic kidney disease (DKD) assessment often relies on invasive renal biopsy.
- Quantifying chronic pathologic changes in DKD is crucial for disease management.
- Shear wave elastography (SWE) is an emerging ultrasound technique for tissue stiffness assessment.
Purpose of the Study:
- To quantitatively analyze renal parenchymal stiffness in advanced DKD using SWE imaging.
- To assess the correlation between renal stiffness and chronic morphological changes in DKD.
- To evaluate SWE's utility in differentiating between chronic kidney disease (CKD) grades in DKD patients.
Main Methods:
- Enrolled 29 diabetic patients with CKD grades 3-4 due to DKD and 23 healthy controls.
- Performed combined conventional ultrasound and SWE imaging on all participants.
- Measured kidney length, width, cortical thickness, and cortical stiffness.
Main Results:
- DKD patients exhibited lower cortical thickness and greater cortical stiffness compared to healthy subjects.
- Cortical stiffness increased with CKD grade (grade 4 > grade 3 > grade 3b > grade 3a) and proteinuria.
- Cortical stiffness showed inverse correlation with estimated glomerular filtration rate and cortical thickness in DKD patients.
Conclusions:
- SWE imaging provides a simple, practical, non-invasive method for evaluating chronic morphological changes in advanced DKD.
- Renal parenchymal stiffness measured by SWE correlates with DKD severity and CKD staging.
- SWE may aid in differentiating between CKD grades in patients with advanced DKD.
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