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A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
Published on: March 24, 2017
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Current strategies to treat tuberculosis
Anthony T Podany1, Susan Swindells2
1College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, USA.
F1000Research
|November 18, 2016
Summary
Tuberculosis treatment is lengthy and challenging. Recent progress offers new drug regimens and agents to combat active disease, addressing challenges like drug resistance and HIV co-infection.
Area of Science:
- Global Health
- Infectious Diseases
- Pharmacology
Background:
- Tuberculosis (TB) remains a major global health threat, causing significant mortality for over a century.
- Current TB therapies are effective but require long, complex treatment durations.
- TB control is hampered by poor public health infrastructure, the TB-HIV co-epidemic, and rising drug resistance.
Approach:
- This review focuses on the development of novel treatment regimens for active tuberculosis.
- It examines current pathways for developing new TB treatment strategies.
- The review highlights new and repurposed anti-TB agents currently in clinical development.
Key Points:
- Significant advancements are being made in developing new anti-tuberculosis therapies.
- Novel drug regimens aim to shorten treatment duration and improve patient compliance.
- Repurposed drugs offer potential new avenues for treating TB, including drug-resistant forms.
Conclusions:
- Despite historical challenges, the pipeline for TB treatment innovation is robust.
- New therapeutic strategies are crucial for overcoming drug resistance and co-infection hurdles.
- Continued research and development are essential for effective global TB control.
Keywords:
BedaquilineClofazamineDelamanidFluoroquinolonesNitroimidazolesOxazolidinonesPretonamidRifamycinTuberculosisMore Related Videos
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