Related Experiment Video

Updated: Mar 12, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

3.9K

Current progress of human trials using stem cell therapy as a treatment for diabetes mellitus

Shuk Kei Cheng1, Elisse Y Park1, Andjela Pehar1

  • 1Georgetown University School of Medicine, Georgetown University Medical Center Washington DC, USA.

American Journal of Stem Cells
|November 18, 2016
PubMed

Insights

Stem cell therapy shows promise for treating diabetes mellitus, offering potential advantages over traditional insulin injections. Ongoing clinical trials suggest this innovative approach may soon become a viable option for managing diabetes.

Area of Science:

  • Regenerative Medicine
  • Endocrinology
  • Cell Biology

Background:

  • Diabetes mellitus poses a significant global health challenge with severe systemic complications.
  • Current treatments like insulin injections and pancreatic islet transplantation have limitations.
  • Stem cell therapy is an emerging research area for diabetes treatment.

Approach:

  • This review synthesizes current research on stem cell therapy for diabetes mellitus.
  • It examines studies utilizing various stem cell types, including mesenchymal and embryonic stem cells, primarily in animal models.
  • Clinical trial data supporting animal study findings are also considered.

Key Points:

  • Stem cell therapy has demonstrated potential in preclinical animal studies for diabetes treatment.
  • Mesenchymal stem cells and embryonic stem cells are among the types investigated.
  • Clinical trials are validating findings from animal research, showing promising results and identifying limitations.

Conclusions:

  • Stem cell therapy presents prospective advantages compared to conventional diabetes treatments.
  • Ongoing clinical trials indicate its potential as a future therapeutic option for diabetes mellitus.
  • Further research and clinical validation are crucial for widespread adoption.
Keywords:
DiabetesIPS cellsadult stem cellsembryonic stem cellshuman trialsspermatogonial stem cells

More Related Videos

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice10:03

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Published on: November 18, 2022

2.4K
Isolation of Rat Adipose Tissue Mesenchymal Stem Cells for Differentiation into Insulin-producing Cells08:09

Isolation of Rat Adipose Tissue Mesenchymal Stem Cells for Differentiation into Insulin-producing Cells

Published on: August 29, 2022

8.7K

Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.4K
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.2K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.3K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.9K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.8K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.1K