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Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
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Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

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Current stem cell based therapies in diabetes.

Meredith A Lilly1, Meghan F Davis1, Josh E Fabie1

  • 1Georgetown University School of Medicine, Georgetown University Medical Center Washington D.C., USA.

American Journal of Stem Cells
|November 18, 2016
PubMed
Summary
This summary is machine-generated.

Stem cell therapy offers a promising future for diabetes treatment by regenerating insulin-producing cells. Research focuses on induced pluripotent stem cells to potentially eliminate the need for insulin injections.

Keywords:
Stem cellsdiabetes mellitusembryonic stem cellsgermline stem cellsinduced pluripotent stem cellsmesenchymal stem cellsstem cell therapy

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Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
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Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
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Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

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Area of Science:

  • Regenerative Medicine
  • Endocrinology
  • Stem Cell Biology

Background:

  • Diabetes mellitus poses significant personal and societal burdens, historically managed with medication.
  • Pancreatic islet regeneration using stem cells is a key therapeutic target to reduce or eliminate insulin dependency.

Approach:

  • Exploring alternative pluripotency routes, bypassing embryonic stem cell ethical concerns.
  • Utilizing induced pluripotent stem cells (iPSCs) to generate insulin-producing cells for transplantation.
  • Investigating embryonic, induced pluripotent, germline, and mesenchymal stem cells for diabetes treatment.

Key Points:

  • iPSC-derived insulin-producing cells closely mimic endogenous beta-cell function in vivo.
  • Advancements in integration-free induction strategies mitigate oncogenesis risks.
  • Microencapsulation technologies are being developed to prevent autoimmune rejection of transplanted cells.

Conclusions:

  • Stem cell-based therapies, particularly using iPSCs, show great promise for treating diabetes.
  • Overcoming challenges like oncogenesis and transplant rejection is crucial for clinical success.