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Updated: Mar 12, 2026
07:23
An Optimized Protocol for the Efficient Radiolabeling of Gold Nanoparticles by Using a 125I-labeled Azide Prosthetic Group
Published on: October 10, 2016
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Radiolabeled theranostics: magnetic and gold nanoparticles
Saeideh Same1, Ayuob Aghanejad1, Sattar Akbari Nakhjavani2
1Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
Bioimpacts : BI
|November 18, 2016
Summary
Multifunctional nanoparticles, including magnetic and gold types, offer advanced drug delivery systems for simultaneous diagnosis and therapy. These radiolabeled nanoprobes enable targeted imaging and treatment, revolutionizing cancer care.
Area of Science:
- Biomedical Nanotechnology
- Pharmaceutical Sciences
- Radiopharmaceutical Chemistry
Background:
- Nanotechnology advances enable novel nanomaterials for biomedical applications.
- Multifunctional nanoparticles (NPs) are crucial for advanced drug delivery systems (DDSs), including theranostics.
- Radiolabeled NPs offer simultaneous diagnosis and therapy for diseases with minimal side effects.
Approach:
- Review of recent advancements in radiolabeled magnetic and gold nanoprobes.
- Discussion of targeted imaging and therapeutic strategies using these nanoprobes.
- Exploration of surface modifications like PEGylation for enhanced circulation and targeting.
Key Points:
- Functionalized magnetic and gold NPs serve as probes for molecular imaging, photothermal therapy, and targeted drug delivery.
- Receptor-specific radiopharmaceuticals and radioisotopes (e.g., 68Ga, 99mTc) enable localized radiotherapy.
- Surface modification with polymers like PEG creates 'stealth' NPs evading immune clearance for improved drug delivery.
Conclusions:
- Modified magnetic and gold NPs facilitate concurrent diagnosis and therapy for various cancers.
- Nanosystems armed with radioisotopes can combine multimodality imaging with photothermal/photodynamic therapy.
- These nanosystems hold significant promise for revolutionizing cancer treatment and improving patient prognosis.
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