Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

RNA Structure01:19

RNA Structure

8.0K
The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
8.0K
RNA Structure01:23

RNA Structure

79.9K
Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
79.9K
RNA Structure01:23

RNA Structure

29.6K
29.6K
RNA Stability01:53

RNA Stability

36.0K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
36.0K
RNA Stability01:53

RNA Stability

12.1K
12.1K
Nucleic Acid Structure01:25

Nucleic Acid Structure

9.8K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
9.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developing a framework for tracking antimicrobial resistance gene movement in a persistent environmental reservoir.

npj antimicrobials and resistance·2025
Same author

Motifs in SARS-CoV-2 evolution.

RNA (New York, N.Y.)·2023
Same author

Lipschitz continuity under toric equivalence for asynchronous Boolean networks.

Chaos (Woodbury, N.Y.)·2023
Same author

RNA Secondary Structures with Given Motif Specification: Combinatorics and Algorithms.

Bulletin of mathematical biology·2023
Same author

The energy-spectrum of bicompatible sequences.

Algorithms for molecular biology : AMB·2021
Same author

Multiscale Feedback Loops in SARS-CoV-2 Viral Evolution.

Journal of computational biology : a journal of computational molecular cell biology·2020

Related Experiment Video

Updated: Mar 12, 2026

Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen
11:32

Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen

Published on: May 24, 2017

12.7K

Statistics of topological RNA structures.

Thomas J X Li1, Christian M Reidys2

  • 1Biocomplexity Institute of Virginia Tech, Blacksburg, VA, 24061, USA.

Journal of Mathematical Biology
|November 18, 2016
PubMed
Summary

This study analyzes topological RNA structures by genus, revealing distributions of loops and pseudoknots. Researchers developed a new generating function to compute expectation values for various RNA configurations.

Keywords:
FatgraphGenerating functionGenusLoopPseudoknotRNA structureSingularity analysis

More Related Videos

An Assay for Quantifying Protein-RNA Binding in Bacteria
07:02

An Assay for Quantifying Protein-RNA Binding in Bacteria

Published on: June 12, 2019

7.1K
Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
10:34

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells

Published on: December 9, 2022

5.4K

Related Experiment Videos

Last Updated: Mar 12, 2026

Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen
11:32

Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen

Published on: May 24, 2017

12.7K
An Assay for Quantifying Protein-RNA Binding in Bacteria
07:02

An Assay for Quantifying Protein-RNA Binding in Bacteria

Published on: June 12, 2019

7.1K
Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
10:34

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells

Published on: December 9, 2022

5.4K

Area of Science:

  • Computational Biology
  • Bioinformatics
  • Structural Biology

Background:

  • RNA structures are crucial for biological function.
  • Topological properties offer a novel framework for RNA analysis.
  • Understanding RNA folding complexity is key.

Purpose of the Study:

  • To investigate topological RNA structures beyond genus zero.
  • To analyze the distribution of various loop types and pseudoknots.
  • To develop a mathematical framework for RNA topology.

Main Methods:

  • Derivation of a bivariate generating function.
  • Singular expansion for distribution analysis.
  • Computation of expectation values for pseudoknots and knots.

Main Results:

  • Analysis of arcs, stacks, hairpin, interior, and multi-loops.
  • Characterization of H-type pseudoknots, kissing hairpins, and 3-knots.
  • Comparison with uniformly sampled structures of fixed genus.

Conclusions:

  • The study provides a novel method for analyzing complex RNA topologies.
  • The generating function enables detailed insights into RNA structural elements.
  • Results offer a foundation for further research in RNA folding and function.