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Related Concept Videos

Tight Junctions01:29

Tight Junctions

8.3K
Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
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Overview of Cell-Cell Junctions01:14

Overview of Cell-Cell Junctions

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The complex three-dimensional arrangement of cells in any multicellular organism is defined and maintained by interactions of cells with each other and the extracellular matrix. Cell-cell junctions are specialized structures where the multi-protein complexes on one cell interact with the multi-protein complexes on another  cell. These cell junctions are classified  into three main types based on their function — occluding, anchoring, and gap junctions.
Occluding or Tight...
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Overview of Cell-Cell Junctions01:14

Overview of Cell-Cell Junctions

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Inflammation01:38

Inflammation

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Overview
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Adherens Junctions01:24

Adherens Junctions

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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
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Anchoring Junctions01:03

Anchoring Junctions

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Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
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Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
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Tight junctions in skin inflammation.

Katja Bäsler1, Johanna M Brandner2

  • 1Department of Dermatology and Venerology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

Pflugers Archiv : European Journal of Physiology
|November 18, 2016
PubMed
Summary
This summary is machine-generated.

Skin inflammation affects tight junctions (TJs), crucial for skin barrier function. This review explores how TJs are impacted in conditions like dermatitis and infections, highlighting their role in inflammatory skin processes.

Keywords:
BacteriaClaudinEczemaInterleukinOccludinS. aureusZO-1

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Area of Science:

  • Dermatology
  • Immunology
  • Cell Biology

Background:

  • Skin inflammation results from diverse external and internal stimuli.
  • Tight junctions (TJs) form a critical epidermal barrier and regulate keratinocyte functions.
  • TJ proteins are often altered during inflammatory skin conditions.

Purpose of the Study:

  • To review the impact of skin inflammation on TJs.
  • To discuss the role of TJs in inflammatory skin processes.

Main Methods:

  • Literature review of studies on skin inflammation and TJs.
  • Analysis of TJ protein alterations in various dermatitis forms, infections, and UV-irradiated skin.

Main Results:

  • Skin inflammation significantly affects TJ structure and function.
  • Altered TJs are observed in atopic dermatitis, skin infections, and UV-induced inflammation.
  • TJ proteins play a role in keratinocyte proliferation, differentiation, adhesion, and apoptosis.

Conclusions:

  • Tight junctions are integral to skin barrier integrity and keratinocyte homeostasis.
  • Dysregulation of TJs contributes to the pathogenesis of inflammatory skin diseases.
  • Understanding TJ involvement offers potential therapeutic targets for skin inflammation.