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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
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Brain pathway differences between Parkinson's disease patients with and without REM sleep behavior disorder
Mina Ansari1,2, Farzaneh Rahmani1,2, Mahsa Dolatshahi1,2
1Neuroimaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Sleep & Breathing = Schlaf & Atmung
|November 18, 2016
Summary
Parkinson's disease patients with REM sleep behavior disorder (RBD) show distinct white matter changes. These brain abnormalities correlate with faster motor and cognitive decline in Parkinson's disease.
Area of Science:
- Neuroscience
- Neurology
- Radiology
Background:
- REM sleep behavior disorder (RBD) is an early symptom of Parkinson's disease (PD).
- PD patients with RBD experience accelerated motor and cognitive decline.
- Limited research exists on the structural brain changes associated with RBD in PD.
Purpose of the Study:
- To investigate microstructural brain abnormalities in PD patients with and without RBD using Diffusion MRI.
- To compare white matter integrity between RBD-positive and RBD-negative PD groups.
Main Methods:
- Diffusion magnetic resonance imaging (DMRI) was employed.
- Diffusion MRI connectometry, utilizing spin distribution function (SDF), was used for group analysis.
- 23 RBD-positive PD patients were compared with 31 RBD-negative PD patients.
Main Results:
- PD patients with RBD exhibited white matter changes in the cingulum, inferior fronto-occipital fasciculus (IFOF), corticospinal tracts (CST), and middle cerebellar peduncles (MCPs).
- These alterations were identified in both left and right brain hemispheres.
Conclusions:
- White matter changes in the cingulum and IFOF may contribute to faster cognitive decline (visual recognition, visuospatial, executive function) in PD patients with RBD.
- Altered CST structural markers in PD patients with RBD align with their more rapid motor progression.
Keywords:
ConnectometryDiffusion MRIParkinson disease (PD)Quantitative anisotropic (QA)REM sleep behavior disorder (RBD)Spin distribution function (SDF)More Related Videos
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