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Solitary morphoea profunda.

S J Whittaker¹, N P Smith, R R Jones

¹Dermatology Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.

The British Journal of Dermatology

|March 1, 1989

Summary

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This study identifies a distinct scleroderma variant, solitary morphoea profunda, affecting the upper trunk. The condition shows unique histological features and does not lead to systemic involvement over 17 years.

Area of Science:

Dermatology
Pathology
Immunology

Background:

Scleroderma encompasses various fibrotic skin conditions.
Morphoea, a localized form, presents diverse clinical and histological subtypes.

Observation:

Five patients presented with solitary, indurated plaques on the upper trunk.
Histology revealed dense, plasma cell-rich mononuclear infiltrates in the subcutis with sclerosis and hyalinization.

Findings:

Lymphoid aggregates and tissue eosinophilia were noted in some cases.
No spontaneous resolution or systemic involvement observed over 17 years.
Immunohistochemistry showed mixed T and B lymphocytes without immunoglobulin light-chain restriction.

Implications:

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These findings suggest 'solitary morphoea profunda' as a distinct clinical and histological entity.
Further research may clarify the pathogenesis and optimal management of this scleroderma variant.