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The Association between Arrhythmia and Helicobacter pylori Infection: A Meta-Analysis of Case-Control Studies

Jin Yan1,2, Qiang She3,4, Yifeng Zhang5,6

  • 1Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China. yanjinnmu@163.com.

International Journal of Environmental Research and Public Health
|November 18, 2016
PubMed

Insights

Helicobacter pylori (H. pylori) infection is linked to a higher risk of cardiac arrhythmia. Eradicating H. pylori may reduce arrhythmia occurrence, particularly in Asian and African populations.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Gastroenterology

Background:

  • Arrhythmia is a prevalent global condition.
  • Helicobacter pylori (H. pylori) infection affects a significant portion of the world's population.
  • The relationship between H. pylori and cardiac arrhythmia remains unclear.

Purpose of the Study:

  • To investigate the association between H. pylori infection and cardiac arrhythmia.
  • To determine if H. pylori is a risk factor for arrhythmia development.

Main Methods:

  • A meta-analysis was conducted.
  • Studies were systematically searched and selected from PubMed, Embase, Web of Science, and the Cochrane Library.
  • Infection rates and odds ratios were compared between arrhythmia patients and control groups.

Main Results:

  • The H. pylori infection rate was significantly higher in patients with arrhythmia (58.1%) compared to controls (47.8%).
  • H. pylori infection was associated with an increased risk of arrhythmia (OR = 1.797, p < 0.05).
  • Subgroup analysis revealed H. pylori as a risk factor for atrial fibrillation in Asia and Africa.

Conclusions:

  • A correlation exists between H. pylori infection and cardiac arrhythmia.
  • H. pylori eradication may potentially reduce the incidence of arrhythmia, especially in Asian and African populations.

Keywords:
Helicobacter pyloriarrhythmiameta-analysis

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