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Updated: Mar 12, 2026
Capillary Force Lithography for Cardiac Tissue Engineering
Published on: June 10, 2014
Regulation of sequential release of growth factors using bilayer polymeric nanoparticles for cardiac tissue
Mohammad Izadifar1,2, Michael E Kelly1,2,3, Xiongbiao Chen1,4
1Division of Biomedical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, SK, Canada.
Aim:
Cardiac tissue engineering aims to develop engineered constructs for myocardial infarction repair, where a challenge is the control of growth factor (GF) sequential release. Herein, bilayer polymeric nanoparticles composed of a GF-encapsulating core surrounded by rate-regulating shell were developed for sequential GF release.
Materials & Methods:
Single and bilayer polymeric nanoparticles were fabricated, characterized and biologically assessed. A novel 'Geno-Neural model' was developed and validated for rate-programming of the nanoparticles.
Results:
The bilayer nanoparticles featured low burst effect and time-delayed release, and allowed for sequential release of PDGF following co-release of VEGFand bFGF, which promoted angiogenesis.
Conclusion:
The nanoparticulate delivery system, along with the Geno-Neural model, offers great potential for spatiotemporal control of GF release for cardiovascular regenerative medicine.
