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[Sensitivity and antibiotic resistance in infections of the musculoskeletal system]

Argenis Mata-Hernández1, Adrián Huematzin Rivera-Villa, Adrián Miguel-Pérez

  • 1Hospital de Ortopedia, Unidad Médica de Alta Especialidad "Dr. Victorio de la Fuente Narváez", Instituto Mexicano del Seguro Social, Ciudad de México, México. ruben.torres@imss.gob.mx.

Revista Medica Del Instituto Mexicano Del Seguro Social
|November 18, 2016
PubMed
Abstract

Insights

Empirical antibiotic treatment for musculoskeletal infections is crucial. Trimethoprim-sulfamethoxazole offers good sensitivity and low resistance, making it a recommended choice over highly resistant beta-lactams.

Area of Science:

  • Infectious Diseases
  • Orthopedic Surgery
  • Microbiology

Background:

  • Musculoskeletal infections pose significant challenges, including prolonged recovery and implant removal.
  • Chronic infections often result from inadequate empirical antibiotic coverage.
  • Developing effective treatment strategies is vital for patient outcomes.

Purpose of the Study:

  • To analyze antibiotic sensitivity and resistance patterns in musculoskeletal infections.
  • To identify optimal empirical antibiotic choices for these infections.

Main Methods:

  • Retrospective, observational, descriptive cohort study.
  • Analysis of germ sensitivity and resistance from infected musculoskeletal system cultures.
  • Inclusion of 143 positive culture results.

Main Results:

  • Staphylococcus aureus (75 cases) and Escherichia coli (31 cases) were the most frequent pathogens.
  • Trimethoprim-sulfamethoxazole, vancomycin, levofloxacin, and linezolid showed good sensitivity.
  • Penicillin G, amoxicillin/clavulanic acid, and ampicillin exhibited high resistance rates.

Conclusions:

  • Trimethoprim-sulfamethoxazole is recommended for empirical treatment due to high sensitivity and low resistance (7.6%).
  • Vancomycin demonstrates comparable sensitivity to trimethoprim-sulfamethoxazole.
  • High resistance rates in beta-lactams necessitate alternative treatment considerations.
Keywords:
Anti-bacterial agentsBone and bonesDrug resistanceInfection

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