Related Experiment Video
Updated: Mar 12, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Rhabdomyolysis case based on hypothyroidism.
Bilal Katipoglu1, Ihsan Ates1, Fatih Acehan1
1Department of Internal Medicine , Ankara Numune Training and Research Hospital, Ankara , Turkey.
Severe hypothyroidism can cause rhabdomyolysis and acute kidney injury, especially with poor medication adherence. Evaluating thyroid status is crucial for unexplained kidney problems or muscle symptoms.
Area of Science:
- Nephrology
- Endocrinology
- Internal Medicine
Background:
- Hypothyroidism presents a broad clinical spectrum, with concurrent rhabdomyolysis and acute renal impairment being rare.
- Poor drug compliance in hypothyroidism can precipitate severe clinical manifestations.
Purpose of the Study:
- To report a rare case of severe hypothyroidism leading to rhabdomyolysis and acute kidney injury.
- To highlight the importance of considering thyroid dysfunction in patients with unexplained renal impairment.
Main Methods:
- Case report detailing a patient with severe hypothyroidism and poor drug compliance.
- Clinical and laboratory evaluation of rhabdomyolysis and acute kidney injury.
Main Results:
- The patient presented with severe hypothyroidism, rhabdomyolysis, and acute kidney injury.
- Poor drug compliance was identified as a contributing factor.
Conclusions:
- Hypothyroidism is an uncommon but significant cause of acute kidney injury.
- Thyroid status evaluation is essential in patients with unexplained acute renal impairment or muscle symptoms.
Related Concept Videos
Nephrotic Syndrome I : Introduction
Nephrotic Syndrome II : Assessment and Medical Management
Chronic Kidney Disease III: Interprofessional Care
Chronic Kidney Disease II: Clinical Manifestations
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Lysosomal Hydrolases

