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Genetic Screens

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

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Longitudinal study of family formation in 892 women and 193 men 8 years after visiting the Fertility Assessment and Counselling (FAC) clinic.

Acta obstetricia et gynecologica Scandinavica·2025
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[Freezing of oocytes as fertility preservation for benign medical and social indication].

Ugeskrift for laeger·2025
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Development and validation of a gonadotropin dose selection model for optimized ovarian stimulation in IVF/ICSI: an individual participant data meta-analysis.

Human reproduction update·2024
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Reflections on timing of motherhood - a qualitative online study with women of reproductive age.

BMC women's health·2024
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The prevalence of late-follicular phase progesterone elevation and impact on the ongoing pregnancy rate after fresh and frozen blastocyst transfer. Sub-study of an RCT.

Human fertility (Cambridge, England)·2024
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A Novel Approach to Predicting Early Pregnancy Outcomes Dynamically in a Prospective Cohort Using Repeated Ultrasound and Serum Biomarkers.

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Related Experiment Video

Updated: Mar 12, 2026

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
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[Fertility screening is a new concept].

Kathrine Birch Petersen1, Anders Nyboe Andersen

  • 1kathrine.birch.petersen@regionh.dk.

Ugeskrift for Laeger
|November 19, 2016
PubMed
Summary

The Fertility Assessment and Counselling Clinic offers individual fertility risk assessments to help people achieve their reproductive goals. This proactive approach aims to reduce the need for fertility treatments and prevent involuntary childlessness.

Area of Science:

  • Reproductive Medicine
  • Public Health

Background:

  • Family planning clinics historically focused on contraception.
  • There is a growing need for proactive fertility management to support reproductive life plans.

Purpose of the Study:

  • To introduce a novel pro-fertility service.
  • To provide individual fertility assessments and counselling.
  • To reduce the incidence of involuntary childlessness and the demand for assisted reproductive technologies.

Main Methods:

  • Establishment of the Fertility Assessment and Counselling Clinic in 2011.
  • Individualized assessment of fertility risk factors.
  • Evaluation of ovarian reserve and sperm concentration.

Main Results:

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  • The clinic represents a pioneering initiative in fertility screening.
  • It offers a unique service focused on proactive fertility management.

Conclusions:

  • The clinic aims to empower individuals in achieving their reproductive goals.
  • This model has the potential to decrease reliance on fertility treatments and prevent childlessness.