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Genome Sequences of Two Multidrug-Resistant Proteus mirabilis Strains Harboring CTX-M-65 Isolated from Malaysia

Choo Yee Yu1,2, Geik Yong Ang1,2, Yun Fong Ngeow3

  • 1Division of Genetics and Molecular Biology, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia.

Genome Announcements
|November 19, 2016
PubMed

Insights

Two multidrug-resistant Proteus mirabilis strains from Malaysia were sequenced. These bacteria possess genes for extended-spectrum beta-lactamases, contributing to urinary tract infections.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Proteus mirabilis is an opportunistic pathogen frequently causing hospital-acquired urinary tract infections.
  • Antimicrobial resistance is a growing global health concern, particularly in nosocomial settings.

Purpose of the Study:

  • To present draft genome sequences of two multidrug-resistant Proteus mirabilis strains.
  • To identify antimicrobial resistance determinants within these strains.

Main Methods:

  • Whole-genome sequencing of two P. mirabilis isolates.
  • Bioinformatic analysis to identify genes associated with antimicrobial resistance.

Main Results:

  • Draft genome sequences for two multidrug-resistant P. mirabilis strains isolated from urine in Malaysia were obtained.
  • The sequenced strains harbor a CTX-M-type extended-spectrum beta-lactamase (ESBL) encoding gene.
  • A variety of other antimicrobial resistance genes were identified in both strains.

Conclusions:

  • The genomic data provides insights into the genetic basis of multidrug resistance in P. mirabilis.
  • Understanding these resistance mechanisms is crucial for managing infections caused by this pathogen.

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