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5-HT3 receptor antagonists for the prevention of postoperative shivering: a meta-analysis

Chengmao Zhou1,2, Yu Zhu2, Zhen Liu1

  • 11 Department of Anesthesiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China.

The Journal of International Medical Research
|November 19, 2016
PubMed

Insights

5-HT3 receptor antagonists effectively prevent postoperative shivering, showing comparable efficacy to meperidine in preventing this common complication. This meta-analysis included 14 randomized controlled trials.

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Postoperative shivering is a common complication following anesthesia.
  • 5-HT3 receptor antagonists are a class of drugs with antiemetic properties.

Purpose of the Study:

  • To evaluate the efficacy of 5-HT3 receptor antagonists in preventing postoperative shivering.
  • To compare the efficacy of 5-HT3 receptor antagonists with placebo and meperidine.

Main Methods:

  • A systematic literature search was conducted in PubMed, Cochrane Library, EMBASE, and Web of Knowledge.
  • Fourteen randomized controlled trials (RCTs) involving 980 patients were included in the meta-analysis.
  • Data were independently screened, extracted, and quality assessed by two researchers.

Main Results:

  • The incidence of shivering was significantly lower in the 5-HT3 receptor antagonist groups compared to placebo (RR = 0.48, 95% CI 0.40 - 0.58).
  • No significant difference in shivering incidence was observed between 5-HT3 receptor antagonist groups and meperidine groups (RR = 0.89, 95% CI 0.60 - 1.34).

Conclusions:

  • 5-HT3 receptor antagonists demonstrate efficacy in preventing postoperative shivering.
  • The efficacy of 5-HT3 receptor antagonists in preventing postoperative shivering is comparable to that of meperidine.
Keywords:
HT3 receptor antagonistsanesthesiameperidinemeta-analysisrandomized controlled trialshivering

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