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The asymptotic maximal procedure for subject randomization in clinical trials

Wenle Zhao1, Vance W Berger2,3, Zhenning Yu1

  • 11 Department of Public Health Sciences, Medical University of South Carolina, Charleston, USA.

Statistical Methods in Medical Research
|November 19, 2016
PubMed
Summary

The asymptotic maximal procedure simplifies restricted randomization in clinical trials by using approximate probabilities. This method is a practical alternative to the original maximal procedure for ensuring balanced treatment groups.

Keywords:
Allocation predictabilityasymptotic maximal procedurerandomized controlled trialsubject randomizationtreatment imbalance

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