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Differentiating lipedema and Dercum's disease.

K Beltran¹, K L Herbst²

¹College of Science, University of Arizona, Tucson, AZ, USA.

International Journal of Obesity (2005)

|November 19, 2016

Summary

Lipedema and Dercum's disease (DD) present with painful fat tissue, but differ in hypermobility and type 2 diabetes (DM2) prevalence. Differentiating these conditions aids in targeted treatment for lipedema and DD patients.

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Area of Science:

Medical Science
Endocrinology
Rheumatology

Background:

Lipedema and Dercum's disease (DD) share symptoms like painful subcutaneous adipose tissue (SAT), complicating diagnosis.
Accurate differentiation is crucial for effective patient management and treatment strategies.

Purpose of the Study:

To compare clinical findings, prevalence of type 2 diabetes (DM2), hypermobility, and inflammation markers between lipedema and DD.
To improve the identification and differentiation of lipedema and DD.

Main Methods:

A case series included 94 DD patients, 160 lipedema patients, and 18 with both diagnoses (Lip+DD).
Data collected included clinical features, DM2 prevalence, Beighton score for hypermobility, and Total complement activity (CH50).

Main Results:

Lipedema patients had greater weight, BMI, gynoid SAT, and hypermobility (58%) compared to DD patients (23%).
Type 2 diabetes was more prevalent in DD (16%) than lipedema (6%), while average pain was higher in DD (6/10) versus lipedema (4/10).
Easy bruising was common in lipedema, whereas DD patients more frequently reported abdominal pain, shortness of breath, fibromyalgia, migraines, and lipomas.

Conclusions:

Lower DM2 prevalence in lipedema may relate to protective gynoid fat distribution.
High hypermobility in lipedema suggests a potential comorbidity.
Fat distribution, pain levels, lipomas, and associated disorders help differentiate DD from lipedema.