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Inhibiting MDSC differentiation from bone marrow with phytochemical polyacetylenes drastically impairs tumor

Wen-Chi Wei1, Sheng-Yen Lin1,2, Chun-Wen Lan1,3

  • 1Agricultural Biotechnology Research Center, Academia Sinica, ROC, Taiwan.

Scientific Reports
|November 19, 2016
PubMed

Insights

Oral administration of polyacetylenic glycosides (BP-E-F1) from Bidens pilosa suppresses cancer metastasis by inhibiting myeloid-derived suppressor cells (MDSCs) differentiation and function without causing weight loss.

Area of Science:

  • Immunology
  • Pharmacology
  • Oncology

Background:

  • Myeloid-derived suppressor cells (MDSCs) promote tumor metastasis by evading immune surveillance.
  • MDSCs are recognized as potential therapeutic targets for cancer treatment.

Purpose of the Study:

  • To investigate the anti-metastasis effects of polyacetylenic glycosides (BP-E-F1) from Bidens pilosa.
  • To determine the mechanism by which BP-E-F1 affects MDSCs and tumor metastasis.

Main Methods:

  • A mouse mammary tumor-resection model was used to evaluate BP-E-F1's efficacy.
  • Pharmacokinetic and mechanistic studies were conducted to elucidate BP-E-F1's mode of action.
  • The study analyzed the impact of BP-E-F1 on granulocytic MDSC (gMDSC) differentiation and function.

Main Results:

  • Oral BP-E-F1 administration suppressed tumor metastasis and reduced tumor-induced gMDSC accumulation in mice.
  • BP-E-F1 inhibited gMDSC differentiation and function, thereby exerting anti-metastasis activity.
  • BP-E-F1 suppressed gMDSC differentiation by inhibiting a G-CSF-induced signaling pathway in bone marrow cells.

Conclusions:

  • Plant-derived polyacetylenic glycosides like BP-E-F1 show potential as botanical drugs against metastatic cancers.
  • Targeting gMDSC differentiation via pathways involving bone marrow cells is a promising strategy for cancer therapy.

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