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Related Experiment Videos

Neonatal lupus in twins.

N Lawrence1, C A Bligard, J Storer

  • 1Department of Dermatology, Tulane Medical School, New Orleans, LA 70112.

Southern Medical Journal
|May 1, 1989
PubMed
Summary
This summary is machine-generated.

Neonatal lupus erythematosus (NLE) involves skin lesions, systemic disease, or heart block. Maternal HLA-A1, B8, DR3, DQ2, and DR52 increase NLE risk in infants born to mothers with SS-A/Ro and SS-B/La autoantibodies.

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Area of Science:

  • Immunology
  • Genetics
  • Pediatrics

Background:

  • Neonatal lupus erythematosus (NLE) is a condition affecting infants, presenting with cutaneous lesions, systemic disease, or congenital heart block.
  • Autoantibodies SS-A/Ro and SS-B/La are linked to NLE, but not all infants of positive mothers develop the condition, suggesting other factors are involved.
  • The variable clinical manifestations and incomplete penetrance of NLE necessitate exploration of additional etiologic factors.