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Updated: Mar 11, 2026

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
Patent ductus venosus presenting with cholestatic jaundice in an infant with successful trans-catheter closure using
Anith Chacko1, Celeste Kock2, Jayneel A Joshi3
1Department of Radiology, Steve Biko Academic Hospital, University of Pretoria, Pretoria, South Africa.
Insights
Persistent ductus venosus is a rare cause of infant cholestatic jaundice. Transcatheter occlusion with a vascular plug successfully treated a 5-week-old infant with this condition.
Area of Science:
- Pediatric Gastroenterology
- Neonatal Medicine
- Interventional Cardiology
Background:
- Cholestatic jaundice in infants often presents diagnostic challenges.
- Persistent ductus venosus is an uncommon etiology for neonatal cholestasis.
- Management strategies for ductus venosus-induced cholestasis are not well-established.
Observation:
- A 5-week-old female infant presented with persistent cholestatic jaundice.
- The jaundice was attributed to a persistent ductus venosus.
- The infant experienced complications necessitating intervention.
Findings:
- Successful transcatheter occlusion of the persistent ductus venosus was performed.
- A vascular plug device was utilized for the occlusion.
- The infant's cholestatic jaundice resolved post-procedure.
Implications:
- Transcatheter occlusion is a viable treatment option for persistent ductus venosus causing cholestatic jaundice.
- This case highlights a minimally invasive approach for a rare neonatal condition.
- Further research may explore the efficacy of vascular plug devices in similar pediatric cases.
Abstract:
Persistent ductus venosus as a cause of cholestatic jaundice is very rare. Treatment varies, but is usually reserved for infants in whom complications develop. We report a 5-week-old female infant with cholestatic jaundice caused by a patent ductus venosus and subsequent successful treatment via a transcatheter occlusion using a vascular plug device.
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