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Exploring the Virchow-Robin spaces function: A unified theory of brain diseases
Iype Cherian1, Margarita Beltran1, Ekkehard M Kasper2
1Department of Neurosurgery College of Medical Sciences, Bharatpur, Chitwan, Nepal.
Background:
Cerebrospinal fluid (CSF) transport across the central nervous system (CNS) is no longer believed to be on the conventional lines. The Virchow-Robin space (VRS) that facilitates CSF transport from the basal cisterns into the brain interstitial fluid (ISF) has gained interest in a whole new array of studies. Moreover, new line of evidence suggests that VRS may be involved in different pathological mechanisms of brain diseases.
Methods:
Here, we review emerging studies proving the feasible role of VRS in sleep, Alzheimer's disease, chronic traumatic encephalopathy, and traumatic brain injury (TBI).
Results:
In this study, we have outlined the possible role of VRS in different pathological conditions.
Conclusion:
The new insights into the physiology of the CSF circulation may have important clinical relevance for understanding the mechanisms underlying brain pathologies and their cure.
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