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Related Concept Videos

Septins01:19

Septins

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Septins are protein filaments forming the cytoskeleton along with the microtubules, microfilaments, intermediate filaments, and other accessory proteins. In 1971 while studying the cell division cycle in mutant Saccharomyces cerevisiae Harwell et al. first identified the septin-related genes playing a crucial role in yeast cytokinesis. Fluorescence microscopy revealed that these proteins localize at the budding neck as rings. These ring-like proteins were then named Septins by John Pringle, and...
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Role of Septins01:02

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Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
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Yeast Signaling01:28

Yeast Signaling

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Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
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Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

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Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
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The Contractile Ring02:15

The Contractile Ring

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Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
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Overview of Secretory Vesicles01:33

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Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
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Related Experiment Video

Updated: Mar 11, 2026

Purification and Quality Control of Recombinant Septin Complexes for Cell-Free Reconstitution
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Purification and Quality Control of Recombinant Septin Complexes for Cell-Free Reconstitution

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Septin Organization and Functions in Budding Yeast.

Oliver Glomb1, Thomas Gronemeyer1

  • 1Department of Molecular Genetics and Cell Biology, Ulm University Ulm, Germany.

Frontiers in Cell and Developmental Biology
|November 19, 2016
PubMed
Summary

Septins, GTP-binding proteins in eukaryotes, form filaments crucial for cell division. This review covers recent structural and cell biology findings in yeast septins.

Keywords:
GTPasebudding yeastcrystal structurecytokinesisseptins

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Septins are conserved GTP-binding proteins found in most eukaryotic cells, excluding plants.
  • First discovered in baker's yeast (Saccharomyces cerevisiae), they remain a key model for septin research.
  • In yeast, septins assemble into ordered filament arrays at the mother-bud neck, regulating spatial organization and cytokinesis.

Conclusions:

  • Recent research has elucidated key structural and functional aspects of yeast septins.
  • Septins are essential for proper cell division and spatial organization in yeast.
  • Continued investigation in Saccharomyces cerevisiae promises further insights into septin biology.