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Regulation of gene expression and mitochondrial dynamics by SMAD
1Division of Pharmacology, College of Pharmacy , Columbus, OH, USA.
Molecular & Cellular Oncology
|November 19, 2016
Abstract:
Mothers against decapentaplegic homolog (SMAD) proteins exert a wide spectrum of transcriptional effects in different cell types and tissues in response to transforming growth factor-β (TGF-β). A recent study demonstrates what is thought to be the first distinct cytoplasmic function for SMAD2 in modulating mitochondrial dynamics and hence reveals new pathophysiological implications for TGF-β signaling.
