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Decreased expression of interleukin-2 binding molecules (p70/75) in T cells from patients with systemic lupus

T Tanaka1, O Saiki, S Negoro

  • 1Third Department of Internal Medicine, Osaka University, Japan.

Arthritis and Rheumatism
|May 1, 1989
PubMed

Using radiolabeled interleukin-2 (IL-2), affinity cross-linking and binding assays revealed that the expression of intermediate-affinity IL-2 binding molecules (p70/75) on freshly prepared T cells from patients with systemic lupus erythematosus (SLE) was significantly decreased in comparison with that in normal subjects. The proliferative response of T cells to high doses of IL-2 was also reduced in patients with SLE. The decreased expression of p70/75 reflects the hyporesponsiveness to IL-2 of T cells in patients with SLE.

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