Related Experiment Video
Updated: Mar 11, 2026

Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation
Published on: June 21, 2021
Thiol/disulfide homeostasis in postmenopausal osteoporosis
V Korkmaz1, Z Kurdoglu2, M Alisik3
1Department of Obstetrics and Gynecology, Ankara Training and Research Hospital, Ankara, Turkey. korkmazvakkas@gmail.com.
Aim:
To evaluate the impact of postmenopausal osteoporosis on thiol/disulfide homeostasis.
Materials And Methods:
A total of 75 participants were divided into two groups: Group 1 (n = 40) was composed of healthy postmenopausal women, and group 2 (n = 35) was composed of women with postmenopausal osteoporosis. Clinical findings and thiol/disulfide homeostasis were compared between the two groups.
Results:
The disulfide/native thiol ratio was 8.6% ± 3.6 in group 1 and 12.7% ± 8.4 in group 2 (p = 0.04). The disulfide/native thiol percent ratio was significantly higher in group 2 after adjustment for the years since menopause and age (p < 0.05). The native thiol/total thiol percent ratio was 85.6% ± 4.8 in group 1 and 73.8% ± 24.9 in group 2 (p = 0.01). The native thiol/total thiol percent ratio was significantly lower in group 2 after adjustment for the years since menopause and age (p < 0.05).
Conclusion:
Thiol/disulfide homeostasis shifted to the disulfide side independent of age and years since menopause in postmenopausal osteoporosis.
More Related Videos
Related Concept Videos
Sulfur Assimilation
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling
Preparation and Reactions of Thiols
Menopause
Structure and Nomenclature of Thiols and Sulfides

