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Related Experiment Video

Updated: Mar 11, 2026

In vivo Imaging of Tumor Angiogenesis using Fluorescence Confocal Videomicroscopy

In vivo Imaging of Tumor Angiogenesis using Fluorescence Confocal Videomicroscopy

Published on: September 11, 2013

Tumor Blood Vessel Visualization.

Clarissa Gillmann¹, Tobias Bäuerle²

¹Institute of Radiology, University Medical Center Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Palmsanlage 5, 91054, Erlangen, Germany.

Methods in Molecular Biology (Clifton, N.J.)

|November 19, 2016

Summary

Noninvasive multimodal imaging techniques like MRI, CT, US, and PET offer detailed insights into tumor blood vessel development. This study demonstrates their application in visualizing breast cancer bone metastasis in rats, providing complementary vascularization data.

Keywords:

Angiogenesis Angiography Computed tomography Dynamic-contrast-enhanced imaging Magnetic resonance imaging Positron emission tomography Tumor vessels Ultrasound

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Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice

Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice

Published on: January 19, 2018

Area of Science:

Biomedical imaging
Oncology
Angiogenesis research

Background:

Tumor angiogenesis is crucial for cancer growth and metastasis.
Noninvasive imaging modalities are essential for longitudinal studies of tumor vascularization.
Assessing tumor blood vessel features aids in understanding cancer progression.

Purpose of the Study:

To review noninvasive multimodal imaging techniques for tumor blood vessel visualization.
To demonstrate the application of MRI, CT, US, and PET in studying breast cancer bone metastasis.
To describe methods for obtaining complementary vascularization data.

Main Methods:

Magnetic Resonance Imaging (MRI)
Computed Tomography (CT)
Ultrasound (US)
Positron Emission Tomography (PET)
Nude rat model of breast cancer bone metastasis

Main Results:

Multimodal imaging allows qualitative and quantitative assessment of tumor angiogenesis.
Complementary data on tumor vascularization can be obtained from various imaging techniques.
The study provides a framework for applying these techniques to specific cancer models.

Conclusions:

Noninvasive multimodal imaging is a powerful tool for studying tumor angiogenesis longitudinally.
Combining MRI, CT, US, and PET offers comprehensive insights into tumor vascular characteristics.
This approach is valuable for preclinical research in cancer metastasis, particularly bone metastasis.