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Coagulation01:06

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Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
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Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
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Reference values for coagulation assessment in full-term newborns.

Lucia Mirabella1, Antonella Cotoia2, Giusj Colacicco2

  • 1Department of Anesthesia and Intensive Care, University of Foggia, Foggia, Italy - lucia.mirabella@unifg.it.

Minerva Anestesiologica
|November 19, 2016
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Summary

Kaolin-activated thromboelastography (TEG®) reference values in newborns are similar to adults, aiding in diagnosing neonatal hemostatic disorders. This study establishes these values for better interpretation of pediatric coagulation tests.

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Area of Science:

  • Neonatal hemostasis and coagulation diagnostics
  • Point-of-care testing in pediatrics
  • Thromboelastography applications

Background:

  • Neonatal coagulation differs from adults, complicating diagnosis and treatment of bleeding disorders.
  • Lack of age-specific reference values and unreliable tests hinder accurate pediatric coagulation assessment.
  • Thromboelastography (TEG®) offers efficient analysis of blood viscoelastic properties for coagulopathy management in newborns.

Purpose of the Study:

  • Determine kaolin-activated TEG® reference values in healthy, full-term newborns.
  • Establish accurate interpretation guidelines for neonatal TEG® results.
  • Facilitate improved diagnosis and management of hemostatic disorders in neonates.

Main Methods:

  • Kaolin-activated TEG® performed on 85 healthy full-term newborns and 40 healthy adults.
  • Analysis of key TEG® parameters: reaction time, clot formation time, α-angle, maximum amplitude, clot lysis, Functional Fibrinogen, and coagulation index.
  • Utilized small umbilical cord blood samples for testing.

Main Results:

  • Presented reference values for kaolin-activated TEG® in healthy newborns.
  • Observed significant variability in reaction time, clot formation time, and coagulation index.
  • No significant differences in TEG® range values were found between neonates and adults.

Conclusions:

  • Neonatal coagulation test results are comparable to adult standards.
  • While age-related differences in kaolin-activated TEG® variables are not significant, further evaluation of TEG® in pediatrics is warranted.
  • Study findings provide a basis for interpreting neonatal TEG® data.