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Cycloartane-type triterpenoids from Astragalus hoantchy French
Kai Guo1, Xiaofeng He1, Dengxue Lu2
1a Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province , Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou , P.R. China.
Abstract:
A new cycloartane-type triterpenoid, 3β-acetoxy-9β,19-cyclolanost-24E-ene-1α,16β-diol-27-O-β-d-glucopyranoside (1), together with three known ones (2-4) were isolated from the aerial parts of Astragalus hoantchy. The structure of compound 1 was elucidated by detailed spectroscopic analyses including 1D and 2D NMR, HRESIMS, and IR experiments. All of the four compounds were isolated from A. hoantchy for the first time. The antifungal activities of compounds 1-4 against a phytopathogenic fungus (Alternaria solani) were evaluated with the result that compound 3 exhibited a moderate activity with an IC50 value of 284 μg/mL.
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