[Rabbit anti-thymocyte globulin, the cause of false-positive results in the microlymphocytotoxicity test?]

The authors describe a positive crossover reaction between serum of a female patient treated with rabbit antithymocytic globulin and donor lymphocytes. In the serum of the patient with inhibition of the bone marrow HLA cytotoxins, thrombolysins, granulocytotoxins and granuloagglutinins were detected. Complete and incomplete thromboagglutinins were not detected. Two days after the positive tests no type of antibodies was detected in the patient's serum. The authors discuss the reasons for the development of the crossover reaction.