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Related Concept Videos

Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

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Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
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Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Related Experiment Video

Updated: Mar 11, 2026

Imaging and Quantification of the Hepatic Vasculature of Mice Using Ultrafast Doppler Ultrasound
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Chronic liver disease: Quantitative MRI vs CEUS-based microperfusion.

M Haimerl, S Poelsterl, L P Beyer

    Clinical Hemorheology and Microcirculation
    |November 19, 2016
    PubMed
    Summary

    Dynamic contrast-enhanced ultrasound (CEUS) perfusion parameters showed potential for assessing liver function, with Wash-In Area Under the Curve (WiAUC), Rise Time (RT), and Wash-in Perfusion Index (WIPI) being significant indicators. However, CEUS could not precisely determine the severity of liver disease in this study.

    Keywords:
    CEUSChronic liver diseaseliver functionmicrocirculation

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    Area of Science:

    • Hepatology and diagnostic imaging.
    • Medical physics and biomedical engineering.

    Background:

    • Accurate assessment of liver function is crucial for managing liver diseases.
    • MRI-based T1 relaxometry and dynamic contrast-enhanced ultrasound (CEUS) offer non-invasive methods for evaluating liver microcirculation and function.

    Purpose of the Study:

    • To compare the diagnostic performance of MRI-based T1 relaxometry with CEUS-based liver microcirculation analysis for assessing liver function.
    • To determine if CEUS parameters can correlate with liver disease severity.

    Main Methods:

    • 22 patients underwent Gd-EOB-DTPA-enhanced MRI with T1 relaxometry and CEUS.
    • MRI T1 relaxometry evaluated the reduction rate of T1 relaxation time (rrT1).
    • CEUS quantified parameters including time to peak (TTP), rise time (RT), Wash-In Area Under the Curve (WiAUC), mean transit time (mTTI), wash-in rate (WiR), and Wash-in Perfusion Index (WIPI).

    Main Results:

    • While TTP, mTTI, and WiR showed no significant difference, RT, WiAUC, and WIPI were significantly lower in patients with impaired liver function compared to healthy controls (p<0.05).
    • No significant correlation was found between CEUS perfusion parameters and MRI-derived rrT1 (p>0.05).
    • CEUS parameters did not accurately assess the severity of liver disease.

    Conclusions:

    • CEUS-based perfusion parameters, specifically WiAUC, RT, and WIPI, can provide a rough assessment of liver function.
    • CEUS was not found to be effective in assessing the severity of liver disease within this study's scope.