A Powerful CD8+ T-Cell Stimulating D-Tetra-Peptide Hydrogel as a Very Promising Vaccine Adjuvant
Zichao Luo1, Qinjie Wu2, Chengbiao Yang3
1Institute of Biomaterials and Engineering, Wenzhou Medical University, Wenzhou Institute of Biomaterials and Engineering, CNITECH, CAS, Wenzhou, 325035, P. R. China.
Abstract:
A novel vaccine adjuvant based on a supramolecular hydrogel of a D-tetra-peptide is reported. Antigens can be easily incorporated into the hydrogel by a vortex or by gently shaking before injection. The vaccines can stimulate strong CD8+ T-cell responses, which significantly inhibits tumor growth. This novel adjuvant is expected to enable a wide range of sub-unit vaccines and help the production of antibodies.
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