Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.8K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.8K
Adult Stem Cells01:33

Adult Stem Cells

34.0K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
34.0K
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

6.6K
Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ASO Visual Abstract: Sentinel Node Biopsy in the Neck Management of cN0 Sinonasal Squamous Cell Carcinoma-A Multicenter Pilot Trial on Safety and Feasibility.

Annals of surgical oncology·2026
Same author

Human immunosuppressive neutrophils: recent answers to old and new questions.

The EMBO journal·2026
Same author

Expert opinion on burning questions in cancer myeloid cell biology.

Journal for immunotherapy of cancer·2026
Same author

Choanal atresia repair in Europe and the world - a comprehensive investigation of the current state of care.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026
Same author

Sentinel Node Biopsy in the Neck Management of cN0 Sinonasal Squamous Cell Carcinoma: A Multicenter Pilot Trial on Safety and Feasibility.

Annals of surgical oncology·2026
Same author

Spatial distribution and prognostic value of tumor-associated macrophages in head and neck squamous cell carcinomas.

Frontiers in oncology·2026
Same journal

Brent A. Reynolds, pioneer of adult neural stem cell biology.

Stem cells (Dayton, Ohio)·2026
Same journal

CircVapa promotes the abnormal differentiation of small intestinal epithelial stem cells in diabetic state.

Stem cells (Dayton, Ohio)·2026
Same journal

Transforming Growth Factor beta-2 (TGFβ2) Drives Trabecular Meshwork Progenitor Cell Differentiation Through SMAD2/3 Signalling.

Stem cells (Dayton, Ohio)·2026
Same journal

Circular RNA circEGFR overexpression attenuates chemosensitivity and enhances cancer stemness via targeting IGF2BP2/SOX2 in breast cancer cells.

Stem cells (Dayton, Ohio)·2026
Same journal

Regeneration of the mammalian brain: a relic of evolution?

Stem cells (Dayton, Ohio)·2026
Same journal

Mitochondrial transfer technologies with molecular insights into clinical applications.

Stem cells (Dayton, Ohio)·2026
See all related articles

Related Experiment Video

Updated: Mar 11, 2026

Author Spotlight: Isolation and Identification of Mesenchymal Stem Cells Derived from Adipose Tissue of Sprague Dawley Rats
10:50

Author Spotlight: Isolation and Identification of Mesenchymal Stem Cells Derived from Adipose Tissue of Sprague Dawley Rats

Published on: April 7, 2023

4.4K

Adenosine Producing Mesenchymal Stem Cells.

Patrick J Schuler1, Sven Brandau2

  • 1Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany.

Stem Cells (Dayton, Ohio)
|November 19, 2016
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells (MSC) show varied immune regulation capabilities. Some MSC produce adenosine independently, while others need T-cells for immune-modulating ATP metabolite production.

Keywords:
AdenosineHead and neck cancerMesenchymal stem cellsMicroenvironmentTregTumor

More Related Videos

Technique for Obtaining Mesenchymal Stem Cell from Adipose Tissue and Stromal Vascular Fraction Characterization in Long-Term Cryopreservation
05:57

Technique for Obtaining Mesenchymal Stem Cell from Adipose Tissue and Stromal Vascular Fraction Characterization in Long-Term Cryopreservation

Published on: December 30, 2021

4.0K
In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells
09:05

In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells

Published on: August 9, 2017

11.5K

Related Experiment Videos

Last Updated: Mar 11, 2026

Author Spotlight: Isolation and Identification of Mesenchymal Stem Cells Derived from Adipose Tissue of Sprague Dawley Rats
10:50

Author Spotlight: Isolation and Identification of Mesenchymal Stem Cells Derived from Adipose Tissue of Sprague Dawley Rats

Published on: April 7, 2023

4.4K
Technique for Obtaining Mesenchymal Stem Cell from Adipose Tissue and Stromal Vascular Fraction Characterization in Long-Term Cryopreservation
05:57

Technique for Obtaining Mesenchymal Stem Cell from Adipose Tissue and Stromal Vascular Fraction Characterization in Long-Term Cryopreservation

Published on: December 30, 2021

4.0K
In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells
09:05

In Vitro Differentiation of Human Mesenchymal Stem Cells into Functional Cardiomyocyte-like Cells

Published on: August 9, 2017

11.5K

Area of Science:

  • Immunology
  • Stem Cell Biology
  • Metabolomics

Background:

  • The adenosine pathway plays a crucial role in human immune responses.
  • Mesenchymal stem cells (MSCs) are known for their immunomodulatory properties.
  • ATP metabolites, including adenosine, are key mediators in immune regulation.

Discussion:

  • Tissue-specific variations influence MSCs' ability to produce immune-regulatory ATP metabolites.
  • Some MSC populations can generate adenosine autonomously.
  • Other MSC types necessitate T-cell cooperation for adenosine production.

Key Insights:

  • Identifies distinct mechanisms of adenosine production by different MSC populations.
  • Highlights the context-dependent immunomodulatory capacity of MSCs.
  • Underscores the importance of cellular cooperation in immune regulation.

Outlook:

  • Further research into MSC-T-cell interactions could reveal novel therapeutic strategies.
  • Understanding tissue-specific differences in MSC function is critical for regenerative medicine.
  • Exploring the role of ATP metabolites in immunology offers new avenues for immune modulation.