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Acotiamide improves stress-induced impaired gastric accommodation
1Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Neurogastroenterology and Motility
|November 19, 2016
Summary
Acotiamide prolonged gastric accommodation and improved stress-induced impairment in guinea pigs. This suggests acotiamide may treat functional dyspepsia by enhancing gastric accommodation reactions.
Area of Science:
- Gastroenterology
- Pharmacology
- Neurogastroenterology
Background:
- Gastric accommodation is crucial for gastric reservoir function.
- Psychological stress, like anxiety, impairs gastric accommodation.
- Acotiamide's effect on stress-induced gastric accommodation impairment was unknown.
Purpose of the Study:
- To investigate acotiamide's effect on gastric accommodation.
- To assess acotiamide's efficacy in a model of stress-induced impaired gastric accommodation.
Main Methods:
- Gastric accommodation was measured by intrabag pressure in guinea pigs after liquid meal ingestion.
- Water-avoidance stress was used to induce stress.
- Acotiamide or nizatidine was administered subcutaneously; fecal output was measured.
Main Results:
- Acotiamide prolonged liquid meal-induced gastric accommodation.
- Water-avoidance stress significantly inhibited gastric accommodation.
- Acotiamide pretreatment improved stress-induced impaired gastric accommodation and increased fecal output.
Conclusions:
- Acotiamide prolongs gastric accommodation.
- Acotiamide effectively improves stress-induced impaired gastric accommodation.
- Acotiamide shows potential for treating functional dyspepsia via improved gastric accommodation.
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