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Updated: Mar 11, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Salmonella in Swine: Microbiota Interactions.

Hyeun Bum Kim¹, Richard E Isaacson²

¹Department of Animal Resources Science, Dankook University, Cheonan, Chungnam, South Korea 31116;

Annual Review of Animal Biosciences

|November 19, 2016

Summary

Salmonella enterica persists in pigs by exploiting host immune responses and altering the gut microbiome. Understanding these interactions is key to preventing Salmonella colonization in swine.

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Area of Science:

Microbiology
Veterinary Science
Immunology

Background:

Salmonella enterica is a significant foodborne pathogen that establishes infection in pigs through complex host-pathogen-microbiome interactions.
Successful colonization by S. enterica requires overcoming the pig's immune defenses and the protective effects of the indigenous gut microflora.
The host's inflammatory response to S. enterica paradoxically provides beneficial metabolites for the pathogen, aiding its survival and competitive advantage.

Purpose of the Study:

To review the existing literature on the intricate interactions between swine, Salmonella enterica, and the indigenous microflora.
To discuss the mechanisms by which S. enterica evades host immunity and colonizes pigs.
To explore strategies for reducing or preventing S. enterica colonization in swine populations.

Keywords:

control of Salmonella enterica gut health innate immunity metabolism microbiome

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Published on: August 11, 2014

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Last Updated: Mar 11, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Chronic Salmonella Infected Mouse Model

Chronic Salmonella Infected Mouse Model

Published on: May 31, 2010

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages

Published on: August 11, 2014

Main Methods:

Literature review of scientific publications on Salmonella enterica in swine.
Analysis of host-pathogen interactions, including immune evasion and metabolite utilization.
Examination of the role of the indigenous microflora in colonization resistance.
Discussion of potential intervention methods.

Main Results:

Salmonella enterica utilizes host-derived metabolites from inflammation for competitive advantage.
Infection-induced dysbiosis of the indigenous microflora correlates with a breakdown in colonization resistance.
Even healthy, low-level Salmonella shedders exhibit altered gut microflora, similar to sick animals.

Conclusions:

Salmonella enterica employs sophisticated strategies to colonize pigs, manipulating host immunity and the gut microbiome.
Alterations in the swine gut microbiome are critical indicators of susceptibility and shedding.
Further research into these interactions can inform the development of effective control measures against Salmonella in pigs.