Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rh Blood Group01:19

Rh Blood Group

4.0K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
4.0K
Development of Immunocompetence01:22

Development of Immunocompetence

1.1K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.1K
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

84
Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
84
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

15.3K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
15.3K
Transcytosis of IgG01:15

Transcytosis of IgG

4.4K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A CBC drawn postnatally from umbilical cord blood can provide valuable diagnostic information for infants admitted to the NICU.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Kernicterus Continues to Occur in the USA Despite Concerted Preventive Efforts.

Case reports in pediatrics·2026
Same author

Designing and implementing a clinical decision support tool to improve compliance with NICU transfusions.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Transfusion Histories of Neonates Who Developed Severe Retinopathy of Prematurity.

Neonatology·2026
Same author

Reference intervals for circulating nucleated red blood cell counts of neonates, improved by the refineR algorithm.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Etranacogene dezaparvovec in people with hemophilia B and without adeno-associated virus serotype 5 neutralizing antibodies: a 4-year subgroup analysis of the Health Outcomes with Padua Gene; Evaluation in Hemophilia B (HOPE-B) trial.

Research and practice in thrombosis and haemostasis·2026

Related Experiment Video

Updated: Mar 11, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

7.0K

Neonatal nonimmune hemolytic anemia.

Hassan M Yaish1, Robert D Christensen, Richard S Lemons

  • 1aDivision of Hematology/Oncology, Department of Pediatrics, University of Utah School of Medicine bPrimary Children's Hospital, Salt Lake City, Utah, USA.

Current Opinion in Pediatrics
|November 19, 2016
PubMed
Summary

Diagnosing neonatal hemolytic anemia is complex. New diagnostic tools like Eosin-5-maleimide (EMA) and next-generation sequencing (NGS) help identify the exact cause of hemolysis in newborns.

More Related Videos

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
07:57

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Published on: August 25, 2022

3.6K
Author Spotlight: Advancing In Vitro Blood Cell Production with Single-Cell Multiomics and Functional Genomics
04:11

Author Spotlight: Advancing In Vitro Blood Cell Production with Single-Cell Multiomics and Functional Genomics

Published on: March 15, 2024

1.7K

Related Experiment Videos

Last Updated: Mar 11, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

7.0K
Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
07:57

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Published on: August 25, 2022

3.6K
Author Spotlight: Advancing In Vitro Blood Cell Production with Single-Cell Multiomics and Functional Genomics
04:11

Author Spotlight: Advancing In Vitro Blood Cell Production with Single-Cell Multiomics and Functional Genomics

Published on: March 15, 2024

1.7K

Area of Science:

  • Neonatal Medicine
  • Hematology
  • Diagnostic Technologies

Background:

  • Anemia in newborns can stem from erythropoietic failure, hemorrhage, or hemolysis.
  • Diagnosing neonatal hemolytic conditions presents challenges due to numerous available tests.
  • A rational, consistent, and cost-effective diagnostic approach is needed for neonatal hemolysis.

Purpose of the Study:

  • To provide expert opinion on rational, consistent, and cost-effective diagnostic methods for neonatal hemolytic conditions.
  • To review recent advances in diagnosing nonimmune hemolytic disorders in neonates.

Main Methods:

  • Review of recent diagnostic advancements in neonatal hemolytic disorders.
  • Highlighting flow cytometry-based Eosin-5-maleimide (EMA) uptake for Red Blood Cell (RBC) membrane defect screening.
  • Discussing next-generation sequencing (NGS)-based panels for identifying causative mutations in hemolysis.

Main Results:

  • EMA uptake via flow cytometry serves as an effective screening tool for RBC membrane defects.
  • NGS-based panels enable precise identification of genetic mutations underlying neonatal hemolysis.
  • These newer tools facilitate the diagnosis of specific, previously undiagnosed hemolytic conditions.

Conclusions:

  • The integration of EMA and NGS significantly enhances the diagnostic capabilities for neonatal hemolytic processes.
  • These advanced technologies allow for the identification of exact causes of hemolysis and discovery of novel mutations.
  • Neonatal practitioners can achieve more precise diagnoses and potentially uncover new genetic links to hemolytic disorders.