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Elevated preoperative HMGB1 as predictor of myocardial injury post-percutaneous coronary intervention

Peng Jin1, Qi Zhou, Shujiang Song

  • 1Department of Cardiology, China National Petroleum Corporation Central Hospital, Langfang, Hebei, China Department of Cardiology, Affiliated Hospital of Hebei University, Baoding, Hebei, China.

Medicine
|November 19, 2016
PubMed

Insights

Preoperative high mobility group box 1 (HMGB1) levels predict myocardial injury after percutaneous coronary intervention. Elevated HMGB1 is linked to worse clinical outcomes and higher injury markers post-procedure.

Area of Science:

  • Cardiology
  • Biomarkers
  • Interventional Cardiology

Background:

  • High mobility group box 1 (HMGB1) is implicated in inflammatory processes.
  • The role of preoperative HMGB1 in percutaneous coronary intervention (PCI)-related myocardial injury requires further elucidation.

Purpose of the Study:

  • To investigate the association between preoperative high mobility group box 1 (HMGB1) levels and myocardial injury following percutaneous coronary intervention (PCI).
  • To assess the impact of preoperative HMGB1 on clinical outcomes in patients undergoing PCI.

Main Methods:

  • A cohort of 302 patients undergoing PCI was stratified into tertiles based on preoperative HMGB1 levels.
  • Cardiac injury markers (creatine kinase-MB, troponin I) were measured post-PCI.
  • Clinical outcomes were monitored for 1-year follow-up.

Main Results:

  • Patients with elevated preoperative HMGB1 levels exhibited a significantly higher incidence of post-procedural myocardial injury.
  • Higher peak creatine kinase-MB and troponin I levels were observed in patients with elevated HMGB1.
  • Elevated HMGB1 was associated with significantly worse event-free survival.

Conclusions:

  • Preoperative high mobility group box 1 (HMGB1) is a significant predictor of myocardial injury after percutaneous coronary intervention (PCI).
  • Elevated HMGB1 levels correlate with adverse clinical outcomes and increased cardiac damage post-PCI.

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