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Contact sensitization in Dutch children and adolescents with and without atopic dermatitis - a retrospective analysis

Stefanie Lubbes1, Thomas Rustemeyer2, Johannes H Sillevis Smitt1

  • 1Department of Dermatology, Academic Medical Centre, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.

Contact Dermatitis
|November 19, 2016
PubMed

Insights

Children with atopic dermatitis show similar contact sensitization rates but react more to lanolin alcohol and fragrances. Patch testing beyond the European baseline series is recommended for accurate diagnosis in pediatric allergic contact dermatitis.

Area of Science:

  • Pediatric Dermatology
  • Allergic Contact Dermatitis
  • Immunology

Background:

  • Allergic contact dermatitis (ACD) affects children with and without atopic dermatitis.
  • Limited data exists on contact sensitization profiles in these pediatric groups.
  • Understanding allergen prevalence is crucial for diagnosis and management.

Purpose of the Study:

  • To identify common allergens in children with and without atopic dermatitis.
  • To compare contact sensitization patterns between these two pediatric groups.
  • To inform diagnostic strategies for suspected ACD in children.

Main Methods:

  • Retrospective analysis of 1012 children aged 0-17 years undergoing patch testing (1996-2013).
  • Comparison of positive reaction rates and specific allergen sensitivities.
  • Inclusion of children with and without a history of atopic dermatitis.

Main Results:

  • Overall, 46% of children showed positive patch test reactions.
  • Children with atopic dermatitis had higher reactivity to lanolin alcohol and fragrances (fragrance mix I, Myroxylon pereirae).
  • Cocamidopropyl betaine and Amerchol L-101 were frequent allergens, particularly in children with atopic dermatitis.

Conclusions:

  • Sensitization prevalence is similar in children with and without atopic dermatitis.
  • Atopic dermatitis is associated with increased sensitivity to lanolin alcohol and specific fragrances.
  • Expanded patch testing, beyond the European baseline series, is beneficial for identifying key allergens like cocamidopropyl betaine and Amerchol L-101.
Abstract

Keywords:
allergic contact dermatitisatopic dermatitischildrencontact allergycontact dermatitisdelayed-type hypersensitivitypatch testing

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