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Hemostatic Findings in Ascitic Fluid: A Cross-Sectional Study in 70 Dogs
Journal of Veterinary Internal Medicine
|November 19, 2016
Summary
Canine ascitic fluid exhibits coagulation activation and fibrinogenolytic/fibrinolytic activity, indicated by low fibrinogen and elevated fibrin-fibrinogen degradation products (FDPs) and D-dimer. This occurs regardless of the ascites cause.
Area of Science:
- Veterinary Medicine
- Comparative Pathology
- Hemostasis and Thrombosis
Background:
- Ascitic fluid in horses and humans demonstrates fibrinolytic activity.
- This activity is independent of the fluid formation mechanism.
Purpose of the Study:
- To investigate coagulation and fibrinogenolytic/fibrinolytic activity in canine ascitic fluid.
- To determine if this activity is present across all types of canine ascites.
Main Methods:
- A cross-sectional study involving 70 dogs with various types of ascites.
- Categorization of ascites into four groups based on pathophysiology.
- Measurement of fibrinogen, fibrin-fibrinogen degradation products (FDPs), and D-dimer in ascitic fluid and plasma.
Main Results:
- Ascitic fluid showed significantly lower fibrinogen concentrations compared to plasma.
- Ascitic fluid had significantly higher FDPs and D-dimer concentrations than plasma.
- These findings were consistent across all four types of ascites studied.
Conclusions:
- Canine ascitic fluid displays evidence of coagulation activation.
- Fibrinogenolytic/fibrinolytic activity is present in canine ascites.
- This activity is independent of the underlying cause of ascites.
