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Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
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Nanoparticle-Based Targeting and Detection of Microcavities.

Nathan A Jones1,2, Sywe-Ren Chang3, William J Troske2,4

  • 1Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.

Advanced Healthcare Materials
|November 19, 2016
PubMed
Summary

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Novel nanoparticles detect active dental caries. These bio-based fluorescent starch nanoparticles illuminate only active lesions, aiding dentists in early diagnosis and treatment of tooth decay.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Dental Research

Background:

  • Dental caries is the most common global oral disease.
  • Current diagnostic methods, like mirror and probe, struggle to differentiate active from inactive lesions.
  • There is a need for improved diagnostic tools for early caries detection.

Purpose of the Study:

  • To develop novel bio-based nanoparticles for specific in vitro detection of active dental caries.
  • To create a diagnostic tool that fluoresces upon detecting active caries and degrades into non-toxic compounds.
  • To enhance the early diagnosis of active carious lesions.

Main Methods:

  • Development of cationic fluorescein-labeled food-grade starch nanoparticles.
  • Illumination of nanoparticles with a standard dental curing light for fluorescence detection.
Keywords:
active carious lesionbiopolymercariesdiagnosisfluorescencenanoparticle

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  • In vitro testing on extracted human teeth using two-photon microscopy for validation.

    • Main Results:

    • Cationic fluorescent nanoparticles (101 ± 56 nm, +5.8 ± 1.2 mV) selectively illuminated active caries.
    • No fluorescence was observed on healthy tooth surfaces.
    • Two-photon microscopy confirmed nanoparticle accumulation in microscopic carious enamel pores.

    Conclusions:

    • Novel bio-based nanoparticles offer a specific method for detecting active dental caries in vitro.
    • These nanoparticles can assist dentists in the early diagnosis of active carious lesions.
    • The technology has the potential to significantly improve dental treatment outcomes.