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Published on: August 7, 2021
Eukaryotic Ribosome as a Target for Cardiovascular Disease
Simone Pellegrino1, Gulnara Yusupova1
1Department of Integrated Structural Biology, Institute of Genetics and Molecular and Cellular Biology, 1 rue Laurent Fries, BP 10142, Illkirch 67404, France; Centre National de Recherche Scientifique (CNRS) UMR 7104, Illkirch 67404, France; Institut National de Santé et de Recherche Médicale (INSERM) U964, Illkirch 67404, France; Université de Strasbourg, Strasbourg 67081, France.
Abstract:
Cardiovascular diseases have been associated with genetic variants and increased plasma level of the secreted protein PCSK9. In this issue of Cell Chemical Biology, Petersen et al. (2016) describe an inhibitor of PCSK9 secretion in human cells that, surprisingly, targets the 80S ribosome.
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