Cancer Cell Drug Response Transcriptomes in 3D

The relevance of different in vitro culture models of cancer cells is a hot topic, but few systematic and definitive analyses in this area exist. In this issue of Cell Chemical Biology, Senkowski et al. (2016) address this issue by studying the transcriptomic profiles of drug-treated cancer cells cultured in two-dimensional and three-dimensional cultures. They describe biological findings with potential therapeutic implications and provide a unique data resource to mine.