Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

4.1K
4.1K
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

19.3K
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
19.3K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

8.8K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
8.8K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

3.2K
3.2K
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

9.9K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
9.9K
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

2.1K
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease.

eLife·2026
Same author

Non-coding structural variants disrupt FOXG1 transcriptional regulation in early neurodevelopment.

Nature communications·2026
Same author

Cis-regulatory evolution shapes facial diversity in birds and mammals.

Science advances·2026
Same author

Multi-season analysis reveals hundreds of drought-responsive genes in sorghum.

The Plant journal : for cell and molecular biology·2026
Same author

Functional architecture of cardiac TF regulatory landscapes in control of mammalian heart development.

bioRxiv : the preprint server for biology·2026
Same author

An expanded registry of candidate cis-regulatory elements.

Nature·2026

Related Experiment Video

Updated: Mar 11, 2026

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

3.1K

The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome.

Cailyn H Spurrell1, Diane E Dickel1, Axel Visel2

  • 1MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Cell
|November 19, 2016
PubMed
Summary
This summary is machine-generated.

This study maps gene regulatory interactions using chromosome conformation capture (3C) and DNA enrichment. It highlights recent advances in understanding cell-specific gene promoter interactions.

More Related Videos

A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers
08:12

A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers

Published on: July 18, 2025

768
Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
10:16

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

Published on: June 28, 2018

33.6K

Related Experiment Videos

Last Updated: Mar 11, 2026

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

3.1K
A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers
08:12

A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers

Published on: July 18, 2025

768
Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
10:16

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

Published on: June 28, 2018

33.6K

Area of Science:

  • Genomics
  • Molecular Biology
  • Epigenetics

Background:

  • Understanding gene regulation is crucial for cell function.
  • Distal regulatory elements control gene expression.
  • Mapping interactions between regulatory elements and promoters is challenging.

Purpose of the Study:

  • To review recent progress in mapping gene regulatory interactions.
  • To explore cell-type-specific dynamics of these interactions.
  • To highlight the application of chromosome conformation capture (3C) techniques.

Main Methods:

  • Coupling 3C with molecular enrichment for promoter-containing DNA.
  • Utilizing complementary approaches for interaction mapping.
  • Analyzing lineage- and cell-type-specific interaction dynamics.

Main Results:

  • Systematic mapping of interactions between distal regulatory sequences and target genes is now possible.
  • Recent advances provide deeper insights into gene regulation.
  • Cell-type-specific interaction dynamics are being elucidated.

Conclusions:

  • 3C-based methods are powerful tools for studying gene regulation.
  • Understanding these interactions is key to deciphering cell-specific gene expression.
  • Continued application of these techniques will advance genomic research.