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Human pregnancy-specific beta 1-glycoproteins are coded within chromosome 19
T R Barnett1, W Pickle, P M Rae
1Molecular Diagnostics, Inc., West Haven, CT 06516.
American Journal of Human Genetics
|June 1, 1989
Summary
Researchers identified cDNAs for pregnancy-specific beta 1-glycoproteins (PS beta G), confirming their location on chromosome 19. This contrasts with previous suggestions of PS beta G genes being on chromosomes X and 6.
Area of Science:
- Human Genetics
- Molecular Biology
- Reproductive Medicine
Background:
- Pregnancy-specific beta 1-glycoproteins (PS beta G) are crucial in pregnancy. Their genetic localization has been debated.
- The carcinoembryonic antigen (CEA) gene family shares significant DNA sequence homology.
Purpose of the Study:
- To isolate and characterize cDNAs encoding PS beta G apoproteins.
- To determine the chromosomal location of PS beta G genes.
- To clarify the genetic relationship between PS beta G and the CEA gene family.
Main Methods:
- cDNA isolation and characterization.
- DNA sequencing and sequence homology analysis.
- Chromosomal mapping techniques.
Main Results:
- Isolated and characterized cDNAs coding for PS beta G apoproteins with high sequence similarity to known PS beta Gs.
- Confirmed that PS beta G cDNAs belong to the carcinoembryonic antigen (CEA) gene family.
- Demonstrated that PS beta G sequences are located on human chromosome 19.
Conclusions:
- PS beta G genes are localized to human chromosome 19.
- This finding refutes recent reports suggesting PS beta G genes are on chromosomes X and 6.
- The study clarifies the genetic basis of PS beta G and its relation to the CEA gene family.