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Trachea

Trachea

The trachea, commonly known as the windpipe, is a vital part of the human respiratory system. It serves as a passageway for air to travel between the larynx and the bronchi, allowing oxygen to reach the lungs. Let's explore its anatomical features, dimensions, layers of the tracheal wall, associated muscles, and the functions of its parts.
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of...

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Related Experiment Video

Updated: Mar 11, 2026

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model

Published on: April 1, 2019

Tissue-engineered trachea: A review.

Jia Xian Law¹, Ling Ling Liau², Bin Saim Aminuddin³

¹Tissue Engineering Centre, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000, Cheras, Kuala Lumpur, Malaysia.

International Journal of Pediatric Otorhinolaryngology

|November 20, 2016

Summary

This summary is machine-generated.

Tissue-engineered trachea offers advantages for tracheal replacement. While challenges in cartilage, epithelium, and vasculature formation persist, ongoing research and clinical trials show promise for this regenerative medicine approach.

Keywords:

Bioreactor Cartilage Respiratory epithelium Tissue engineering Tracheal replacement Transplantation

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Last Updated: Mar 11, 2026

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model

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Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue

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Heterotopic and Orthotopic Tracheal Transplantation in Mice used as Models to Study the Development of Obliterative Airway Disease

Heterotopic and Orthotopic Tracheal Transplantation in Mice used as Models to Study the Development of Obliterative Airway Disease

Published on: January 20, 2010

Area of Science:

Regenerative Medicine
Biomaterials Science
Tissue Engineering

Background:

Tracheal replacement is necessary when direct reconnection is impossible after resection.
Tissue-engineered trachea presents a promising alternative to traditional grafts, offering significant advantages.
The complexity of the trachea, with its cartilage, epithelium, and vasculature, poses fabrication challenges.

Purpose of the Study:

To review the current state of tissue-engineered trachea development for grafting.
To discuss the formation of key tracheal components: cartilage, epithelium, and neovascularization.
To highlight obstacles, potential solutions, and future directions in clinical applications.

Main Methods:

Utilizing hollow cylindrical scaffolds (from allografts or biomaterials) for structural support.
Seeding scaffolds with chondrocytes and epithelial cells to promote tissue regeneration.
Employing bioreactors for in vitro tissue development and evaluating clinical trial outcomes.

Main Results:

Successful formation of cartilage, epithelium, and neovascularization in engineered tracheal grafts.
Demonstrated feasibility through several clinical trials for tracheal replacement.
Identified key elements for scaffold design: lateral rigidity and longitudinal flexibility.

Conclusions:

Tissue-engineered trachea shows encouraging results and potential for clinical use.
Obstacles in achieving full functionality and widespread clinical adoption remain.
Further research is needed to overcome current limitations before broad clinical application.