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Updated: Mar 11, 2026
04:29
Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
Published on: January 7, 2019
29.8K
Vagus nerve stimulator-related speech/exercise induced cough
Charlotte Dandurand1, Pierre-Olivier Champagne2, Karim Elayoubi2
1Department of Neurosurgery, University of British-Columbia, Vancouver General Hospital, 855 West 12th Ave, Vancouver V5Z 1M9, Canada.
Summary
Vagal nerve stimulation (VNS) therapy can cause rare side effects like dry cough, even when the device is off. This case report details a patient experiencing cough during speech and exercise after VNS implantation.
Area of Science:
- Neurology
- Psychiatry
- Medical Devices
Background:
- Vagal nerve stimulation (VNS) is an established adjunctive therapy for treatment-resistant depression.
- While generally safe, VNS can induce side effects related to stimulation parameters.
Observation:
- A rare case of dry cough, triggered by speech and mild exercise, was observed.
- This cough occurred specifically during the 'off' mode of the implanted vagal nerve stimulator (VNSor).
Findings:
- This represents the first reported instance of VNS-induced dry cough occurring in the device's off mode.
- The findings suggest a potential mechanism for cough independent of direct electrical stimulation.
Implications:
- Understanding this rare complication is crucial for managing VNS therapy.
- Further research into the pathophysiology may reveal novel treatment strategies for VNS-related side effects.
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