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Related Experiment Video

Updated: Mar 11, 2026

Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations

Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations

Published on: August 22, 2019

Single cell screening approaches for antibody discovery.

Valerie Fitzgerald¹, Paul Leonard¹

¹Vaccinogen Inc., 949 Fell Street, 2nd Floor, Baltimore, MD 21231, United States.

Methods (San Diego, Calif.)

|November 20, 2016

Summary

Microtools enhance single-cell analysis for antibody discovery, overcoming limitations of traditional methods. These advanced technologies improve understanding of biological processes and open new research avenues.

Keywords:

Antibody screening Microtool Single cell analysis

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Last Updated: Mar 11, 2026

Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations

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Published on: August 22, 2019

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Bacterial Inner-membrane Display for Screening a Library of Antibody Fragments

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Published on: October 15, 2016

Area of Science:

Biotechnology
Immunology
Cell Biology

Background:

Single-cell analysis is revolutionizing biological research by enabling in-depth interrogation of individual cells.
Traditional antibody screening methods have limitations that hinder efficient antibody discovery.

Purpose of the Study:

To review microtools for single-cell analysis in antibody discovery.
To compare different microtool technologies and their applications.
To provide an outlook on the future utility of these tools in research.

Main Methods:

Review of current literature on microtools for single-cell analysis.
Comparison of various microtool classes used in antibody discovery.
Analysis of how microtools address limitations in traditional antibody screening.

Main Results:

Microtools offer high-throughput, in-depth analysis of single cells.
These tools complement existing antibody generation methodologies.
Several classes of microtools are available, each with distinct advantages.

Conclusions:

Microtools are significantly advancing antibody discovery by overcoming traditional screening limitations.
The development and application of microtools are expanding possibilities in biological research.
Future utility of microtools in antibody discovery and broader biological research is promising.