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Related Experiment Video

Updated: Mar 11, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

Anti-inflammatory drugs decrease infection of brain endothelial cells with EHV-1 in vitro.

L S Goehring¹, K Brandes², L V Ashton²

¹Ludwig-Maximilians University, Munich, Germany.

Equine Veterinary Journal

|November 20, 2016

Summary

This summary is machine-generated.

Anti-inflammatory drugs reduce equine herpesvirus-1 (EHV-1) endothelial cell infection by limiting cell-to-cell contact. This suggests potential clinical benefits for EHV-1-infected horses during viraemia.

Keywords:

EHM dexamethasone firocoxib horse lidocaine

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Last Updated: Mar 11, 2026

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Published on: July 14, 2020

Area of Science:

Veterinary Virology
Immunology
Pharmacology

Background:

Equine herpesvirus-1 (EHV-1) causes myeloencephalopathy through endothelial cell infection in the spinal cord vasculature.
This infection occurs during cell-associated viraemia and requires contact between infected peripheral blood mononuclear cells (PBMCs) and endothelial cells (ECs).
Inflammation during viraemia may increase adhesion molecule expression, facilitating EC infection.

Purpose of the Study:

To evaluate the efficacy of anti-inflammatory drugs in reducing EHV-1 infection of endothelial cells.
To investigate the role of these drugs in preventing EHV-1 associated myeloencephalopathy.

Main Methods:

An in vitro modified infectious centre assay was employed.
Immortalised or primary endothelial cells were treated with anti-inflammatory drugs or left untreated.
Plaque counts per well were used as the primary outcome measure.

Main Results:

A significant reduction in EHV-1 plaque counts was observed in drug-treated cells compared to untreated controls.
No dose-dependent effect was noted when drug concentrations were increased tenfold.
Effective reduction in plaque counts required treatment of both PBMCs and ECs.

Conclusions:

In vitro, anti-inflammatory drugs decrease EHV-1 endothelial cell infection, likely by reducing PBMC-EC contact.
The specific role of adhesion molecules in this process warrants further investigation.
These findings suggest that anti-inflammatory drug therapy could be clinically relevant for horses experiencing EHV-1 infection and viraemia.