Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Skeletal Muscle Anatomy

Skeletal Muscle Anatomy

Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.

Classification of Skeletal Muscle Fibers

Classification of Skeletal Muscle Fibers

Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Tunable Nanoparticle Thin-Film Reveals Distance Dependence of Auger-Mediated Radiation Enhancement in Diffuse Midline Glioma.

ACS nano·2026

Same author

Developing a Clinically Practical Biomaterial Platform for Endogenous Liver Regeneration.

Gels (Basel, Switzerland)·2026

Same author

Peptoid-Based Nanosheets Exhibiting Broad Antiviral Activity against Enveloped RNA Viruses.

ACS nano·2026

Same author

Pneumatically controlled microfluidic synthesis of polymeric nanoparticles for mRNA delivery.

Nanoscale·2026

Same author

hiPSC-Derived Gingival Epithelium-On-Chip for Modeling Inflammation and Immune Response.

ACS applied materials & interfaces·2026

Same author

Cell and Hydrogel-Integrated Therapies for Intervertebral Disc Regeneration.

Advanced healthcare materials·2025

Search research articles

Related Experiment Video

Updated: Mar 11, 2026

Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation

Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation

Published on: March 19, 2013

Anisotropic Materials for Skeletal-Muscle-Tissue Engineering.

Soumen Jana¹, Sheeny K Lan Levengood¹, Miqin Zhang¹

¹Department of Materials Science & Engineering, University of Washington, Seattle, Washington, 98195, USA.

Advanced Materials (Deerfield Beach, Fla.)

|November 20, 2016

Summary

This summary is machine-generated.

Tissue engineering offers a promising solution for skeletal muscle regeneration, especially for large tissue defects. Anisotropic scaffolds guide cell growth, improving functional restoration beyond current clinical methods.

Keywords:

anisotropic materials micropatterned substrates muscles nanofibers scaffolds tissue engineering

More Related Videos

Assessing Functional Metrics of Skeletal Muscle Health in Human Skeletal Muscle Microtissues

Assessing Functional Metrics of Skeletal Muscle Health in Human Skeletal Muscle Microtissues

Published on: February 18, 2021

High-Throughput Contractile Measurements of Hydrogel-Embedded Intact Mouse Muscle Fibers Using an Optics-Based System

High-Throughput Contractile Measurements of Hydrogel-Embedded Intact Mouse Muscle Fibers Using an Optics-Based System

Published on: May 5, 2023

Related Experiment Videos

Last Updated: Mar 11, 2026

Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation

Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation

Published on: March 19, 2013

Assessing Functional Metrics of Skeletal Muscle Health in Human Skeletal Muscle Microtissues

Assessing Functional Metrics of Skeletal Muscle Health in Human Skeletal Muscle Microtissues

Published on: February 18, 2021

High-Throughput Contractile Measurements of Hydrogel-Embedded Intact Mouse Muscle Fibers Using an Optics-Based System

High-Throughput Contractile Measurements of Hydrogel-Embedded Intact Mouse Muscle Fibers Using an Optics-Based System

Published on: May 5, 2023

Area of Science:

Biomaterials Science
Regenerative Medicine
Tissue Engineering

Background:

Skeletal muscle regeneration is limited, and current treatments fail for extensive tissue loss.
Tissue engineering provides a viable alternative for functional muscle restoration.

Purpose of the Study:

To review fundamental concepts and current approaches in skeletal muscle tissue engineering.
To examine recent advances in anisotropic scaffolds and their impact on cell behavior.
To highlight the potential of anisotropic materials in future clinical applications.

Main Methods:

Review of literature on skeletal muscle tissue engineering.
Analysis of anisotropic scaffold design and fabrication.
Examination of scaffold properties (topographical, mechanical, biochemical) and their influence on cellular function.

Main Results:

Anisotropic scaffolds mimic native muscle extracellular matrix (ECM) morphology.
Scaffold features guide cell alignment, proliferation, and differentiation into myotubes.
Understanding scaffold cues is crucial for optimizing cell function and phenotype.

Conclusions:

Anisotropic scaffolds are key to advancing skeletal muscle tissue engineering.
Recent developments show promise for improved clinical outcomes.
Further research into anisotropic materials will drive future innovations.